The length of her time as No.1, from 23 April 2007 to her retirement in 2 May 2010, at the age of 28, was a US LPGA Tour record.

She finished five shots ahead in the Kraft Nabisco and in the British Open, played over the Old Course in St Andrews, she led from start to finish. She also won the next two LPGA events, the Canadian Open and the Safeway Classic to become the first woman to win three consecutive events since Annika Sörenstam in 2005.

Also in 2007, Lorena became the first woman to earn more than $4 million in a single season, surpassing Sörenstam's previous record of $2,863,904.

She won 27 times on the LPGA Tour and was inducted into the World Golf Hall of Fame in 2017. She was twice nominated, in 2008 and 2009, for the Laureus World Sportswoman of the Year Award.

Lorena’s retirement in 2010 surprised everyone, but she said her career plan had always been to become No.1 player in the world and play professionally for ten years.

She made a return to competitive golf in 2012, having been invited to compete in the Lacoste Ladies French Open, but apart from that she has limited her appearances to her own event, the Lorena Ochoa Invitational, staged at Guadalajara Country Club, which raised funds for the Lorena Ochoa Foundation.

The mission of the foundation is to provide opportunity for children and adults with family-based health, fitness, education and inclusion programmess through golf activities.

She was inducted as a member of the Laureus World Sports Academy on stage at the 2019 Laureus Awards Ceremony.