Stepped away from tennis in 2023 to look after her mental health. When she returned, she was ranked No. 373. In 2025, she defeated each of the world’s top three ranked players. A 6-4, 4-6, 6-4 semi-final victory against Aryna Sabalenka led to a 6-0, 6-0 Wimbledon final defeat to Iga Światek, however, she recovered to beat Światek on home soil 6-4, 6-3 at the US Open. Anisimova went on to win the China Open in October, dispatching world No.2 Coco Gauff 6-1, 6-2 in the semi-final. She also won the title in Doha and achieved a year-end ranking of No.4.